Speaking at CNBC's Invest in America forum, Infantino emphasized that it is important for Iran to be part of the World Cup, even though the team's participation has been questioned since the U.S. and Israel launched airstrikes on the country.
"The Iranian team is coming safely, yes," said Infantino. "We hope that by then, of course, the situation will be calm. As I said, that would certainly help. But Iran must come. Of course, they represent their people. They qualified. The players want to play."
Infantino met with the Iranian team two weeks ago in Antalya, Turkey, and on Wednesday he said he was impressed by what he saw.
"I went to see them. They are actually quite a good team," said Infantino. "And they really want to play and need to play. Sport should now be outside of politics."
At the same time, he acknowledged that separating sport and politics is not always possible.
"OK, we don't live on the Moon, we live on planet Earth," said Infantino. "But you know, if no one else believes in building bridges and maintaining them, keeping them intact and connected, then we do that job."
The United States will host the World Cup together with Canada and Mexico.
According to the current schedule, Iran is set to play two group stage matches in Inglewood, California, and one in Seattle.
The war has further deepened the dilemmas surrounding Iran's participation in the World Cup. Conflicting statements from Iranian state and football officials have emerged in public, while U.S. President Donald Trump has discouraged the Iranian team from coming to the tournament, citing security reasons.