Barrymore mentioned struggling with her self-image after losing a significant amount of weight. "Recently, I was walking down the street and felt how exhausted I am. I had two C-sections. I can't wear many different types of pants. Now I understand that when you have children, you have a hectic life and your body changes, you age, and things just aren't the same," she shared. Additionally, Barrymore spoke about menopause symptoms, describing that she feels like a "dead fish." "I can't help but be honest, I can't act anything out. I'm so bloated that I feel like some carp that was brought to the beach, and I'm just that dead fish," she said. Barrymore expressed feeling unattractive, irritable, and emotionally unstable. The actress has two daughters with her ex-husband Will Kopelman. The couple married in 2012 and divorced in 2016 but have continued to co-parent their children.