Al Jazeera journalist Tohid Asadi, reporting from Tehran, stated that the facility was severely hit, with significant damage reported to the mosque and laboratories within the complex.
"The Sharif area has witnessed other attacks as well, including one on a gas facility. Iran's Ministry of Science and Technology informed us that since the beginning of the war on February 28, at least 30 universities have been hit," said Asadi, adding that other civilian sites across Iran, including roads, power plants, and bridges, have also been targeted.
Mohammad Reza Aref, Iran's first vice president, accused the United States of using a "bunker-buster" bomb to target the university.
"The bunker-buster bomb attack on Sharif University is a symbol of Trump's madness and ignorance. He does not understand that Iran's knowledge is not embedded in concrete to be destroyed by bombs; the real fortress is the will of our professors and elites," Aref wrote in a post on X.
Iran's Foreign Minister Abbas Araghchi accused Israeli-American forces of hitting Sharif University in Tehran, noting that the site was attacked after previous strikes on other universities.
"The Israeli-American aggressors bombed Iran's Massachusetts Institute of Technology (MIT). 1,400 years ago, the Prophet Muhammad (peace and blessings of God be upon him) said that even if knowledge were placed in the distant Pleiades, Iranians would be capable of reaching it. The aggressors will see our power," he wrote on X, alongside photos of the destruction at the university.