With this victory, Mikel Arteta's team ended a streak of two consecutive defeats and returned to the top of the table ahead of City, though they still have one more game played than the Citizens.
The home side did not shine again, securing the win as early as the 10th minute when, after a nice buildup, Eze beautifully struck the left post, sparking an eruption of joy.
A much better performance was expected afterward, especially from the hosts, but under immense pressure, they struggled to create chances and focused more on defense.
In this configuration of forces, Newcastle tried to equalize, coming closest in the 80th minute when Wissa missed a sitter from just five meters out.
The hosts responded a few minutes later, and Saka could have scored in the 81st minute, but his shot went wide of the goal.
The match ended 1-0.
Arsenal leads with 73 points, three more than second-placed City, who have a game in hand.